New One Pot and Efficient Four‐Components Reaction for Synthesis of 2,3‐Dihydrothiophene Carbamate Derivatives

Abstract A new series of 2,3‐dihydrothiophenes bearing ethyl carbamate moiety ( 4 a – l ) was designed and synthesized through facile synthetic route involving domino ring‐opening/recyclization reaction 1,3‐thiazolidinedione. The synthesis achieved via novel one‐pot four‐component aromatic aldehydes, malononitrile 1,3‐thiazolidinedione, using 4‐dimethylaminopyridine as base catalyst under ethanol reflux. molecular structures the compounds were elucidated by usual spectroscopic techniques such FT ‐ IR, 1 H NMR, 13 C NMR HRMS methods. X‐ray diffraction used to confirm d j . Readily available starting materials, atom‐efficient routes employing more mild conditions environmentally benign are attracting features this current protocol.